The PFA Player of the Year award will be contested between Kevin De Bruyne, Mohamed Salah, Harry Kane, David Silva, Leroy Sane and David de Gea.
Voted for by their fellow professionals, this is the individual award that means the most to Premier League players, and six have been recognised for their outstanding contributions throughout the season.
While Salah and De Bruyne are favourites, Sportsmail runs through the reasons why each of the players could deserve to win.
Mohamed Salah and Kevin De Bruyne have been named on the PFA Player of the Year shortlist
Mohamed Salah (Liverpool)
It seems laughable now but when Liverpool brought Mohamed Salah back to the Premier League last summer it was seen as a bit of a gamble.
The Egyptian had already endured one fruitless spell in the top flight as a misfit at Chelsea but rebuilt his career in Italy with a loan spell at Fiorentina, before joining Roma.
His form in Italy persuaded Jurgen Klopp to splash £39million on him and even at that price it has proved an absolute bargain.
The forward needed no time to settle at all since making his debut, helping form one of Europe’s most feared attacks alongside Roberto Firmino and Sadio Mane which have helped him top the Premier League scoring charts. Even the most optimistic Liverpool fan would not have dreamed that at the start of the season.
Key stat: Salah has been involved in 40 of Liverpool’s Premier League goals this term, scoring 30 and assisting 10.
Odds to win: 4/6
Verdict: The favourite to win
Salah moved to 30 Premier League goals for the season with his latest goal vs Bournemouth
Kevin De Bruyne (Manchester City)
Another former Chelsea misfit that has flourished away from Stamford Bridge to emerge as one of Premier League’s most talented players.
Even in Pep Guardiola’s tricky first season, Kevin de Bruyne’s class showed and there has arguably been no player more crucial for Manchester City during their charge towards an inevitable fifth league title.
The Belgian’s creativity has helped City blast home 93 goals this term – at a rate of nearly three a game in one of the most dominant teams the Premier League has seen.
The midfielder has also chipped in with seven goals this term but with just one since Christmas it may harm his chances of winning Player of the Year.
Key stat: De Bruyne has made 15 Premier League assists this term – three more than anyone else.
Odds to win: 11/8
Verdict: Set to be pipped to the line by Salah
Kevin De Bruyne has been chief creator for champions-elect Manchester City this season
Harry Kane (Tottenham Hotspur)
The honours may not be stacking up in the Tottenham trophy cabinet, but the personal accolades continue to role in for Harry Kane.
The striker’s goal scoring exploits have been unrivalled over the past four campaigns as he targets a hat-trick of Premier League golden boot awards that have helped turn Spurs into a team competing at the top in among the Champions League places.
Five goals off the standard set by Salah, the hat-trick of golden boots looks set to elude the England international but can he make up for that with a bid to secure Player of the Year?
Key stat: No Premier League player has scored more than Kane’s 100 goals since the start of the 2014-15 season.
Odds to win: 33/1
Verdict: A dark horse but third place looks most likely
Harry Kane is a dark horse for the award but sits a distance behind De Bruyne and Salah
David Silva (Manchester City)
David Silva has become part of the furniture at Manchester City as he prepares to end an eighth campaign with the club by lifting a third Premier League title.
In a City squad saturated with talent Silva boasts the added quantity of experience. Indeed, City didn’t lose a single game in any competition with the midfielder starting until February in a run spanning 25 games.
De Bruyne’s overall contribution has perhaps meant the Spaniard has been overlooked this term but Silva remains of City’s most important players as he enters the autumn of his career at 32 years old.
Key stat: Only City team-mates De Bruyne and Leroy Sane have made more than Silva’s 11 Premier league assists, and the Spaniard has scored eight goals too.
Odds to win: 50/1
Verdict: Will be worthy of a top-five place
David Silva (pictured) is one of three City players on the six-man shortlist for the award
Leroy Sane (Manchester City)
After a relatively quiet first season at Manchester City following his £37m arrival from Schalke, Sane has gone from hot prospect to key player and has been remarkable at times this term.
It took a year to really adapt to the rigours of English football but Sane’s rapid improvement under Pep Guardiola has not just won over City supporters but has also served to keep a fit-again Marco Reus out of the Germany team.
The 22-year-old, who is also on the shortlist for the Young Player of the Year award alongside team-mates Raheem Sterling and Ederson, has nine goals and 12 assists in the Premier League this season.
Key stat: Sane’s 12 assists this season is the second highest in the Premier League. Only team-mate Kevin De Bruyne (15) has more.
Odds to win: 80/1
Verdict: A contender for Young Player of the Year, but won’t be close to this award.
Leroy Sane was a surprise nomination, but will at least contend for the Young Player award
David de Gea (Manchester United)
For all of Manchester United’s high-profile money-spinning entrances into the transfer market in recent years, there is still perhaps no player more important in the starting XI than David de Gea.
The Premier League title is set to elude Old Trafford once more but that cannot be blamed on the Spaniard who more often than not makes his presence felt through incredible saves rather than being at fault for conceding.
It’s through the 27-year-old’s consistency that has helped him become arguably the best goalkeeper in the world – certainly in the Premier League at least this term where his 16 clean sheets is unmatched.
Key stat: No goalkeeper has won the Player of the Year award since Tottenham Hotspur’s Pat Jennings in 1976.
Verdict: Lack of a Premier League medal this term severely hinders chances.
David De Gea’s form this campaign has seen many people label him the world’s best keeper